Solutions for T cell engager (TCE) programs

May 16, 2025

T cell engagers (TCEs) are bispecific antibodies designed to redirect cytotoxic T cells to pathogenic cells by simultaneously binding CD3 on T cells and disease-associated antigens on target cells.

Key limitations of T cell engager therapies include an incomplete understanding of primary resistance to treatment, which is influenced by the baseline composition of the T cell compartment and acquired resistance that is driven by T cell exhaustion.

In addition to supporting the assessment of safety and efficacy, CellCarta can also help you unravel the mechanisms at play behind primary and acquired resistance to TCE therapies. 

Link to brochure

Solutions for T cell engager (TCE) programs

May 16, 2025

T cell engagers (TCEs) are bispecific antibodies designed to redirect cytotoxic T cells to pathogenic cells by simultaneously binding CD3 on T cells and disease-associated antigens on target cells.

Key limitations of T cell engager therapies include an incomplete understanding of primary resistance to treatment, which is influenced by the baseline composition of the T cell compartment and acquired resistance that is driven by T cell exhaustion.

In addition to supporting the assessment of safety and efficacy, CellCarta can also help you unravel the mechanisms at play behind primary and acquired resistance to TCE therapies. 

Link to brochure

Advance Your ADC Programs with CellCarta

April 16, 2025

Our team developed a comprehensive suite of precision assays to support every stage of antibody-drug conjugate (ADC) development.

From confirming target expression and measuring density, to evaluating drug-target engagement, pharmacokinetics, and safety, CellCarta employs a data-driven, multiplatform approach.

Our solutions include multiplex IF and IHC, flow cytometry, mass spectrometry, RNA sequencing, and spatial biology technologies, ensuring precise target quantification and in-depth tumor microenvironment analysis.

With global facilities, companion diagnostic (CDx) expertise, and full logistics support, CellCarta helps biopharma partners accelerate their ADC programs.

Download the brochure now!

ADC

Advance your ADC programs with CellCarta! Contact us today to discover how our precision assays and scientific expertise can drive your clinical success.

Advance Your ADC Programs with CellCarta

April 16, 2025

Our team developed a comprehensive suite of precision assays to support every stage of antibody-drug conjugate (ADC) development.

From confirming target expression and measuring density, to evaluating drug-target engagement, pharmacokinetics, and safety, CellCarta employs a data-driven, multiplatform approach.

Our solutions include multiplex IF and IHC, flow cytometry, mass spectrometry, RNA sequencing, and spatial biology technologies, ensuring precise target quantification and in-depth tumor microenvironment analysis.

With global facilities, companion diagnostic (CDx) expertise, and full logistics support, CellCarta helps biopharma partners accelerate their ADC programs.

Download the brochure now!

ADC

Advance your ADC programs with CellCarta! Contact us today to discover how our precision assays and scientific expertise can drive your clinical success.

Keep your ADC programs on Target | CellCarta

Keep your ADC programs on Target

Our experts harness our comprehensive suite of precision assays to measure what matters throughout your ADC development. Navigate the complexities of ADC development and approval with our scientific & regulatory expertise.

Discover our ADC expertise. Request a consult today.

On Target:

Our multiplatform approach for reliable ADC analysis ensures you have a complete understanding of your target expression, engagement and ADC pharmacokinetics at all stages of development.

Download the resource

See our precision assays for ADC development

Beyond the target:

In-depth monitoring of the tumor microenvironment (TME) is crucial to understanding why patients may or may not respond to ADCs. We assess immune cell infiltration, activation and exhaustion with multiplatform approaches, plus spatial distribution of cells and targets including both transcriptomic and proteomic profiling.

On-target, off-tumor:

We understand that safety is key. Precisely assessing on-target, off-tumor ADC toxicity identifies concerns early.

On track for approval:

We conduct all assays using CAP/CLIA-accredited laboratories, ensuring the highest standards for regulatory compliance. Our team supports your pathway to approval with extensive knowledge on IVDR and HGRAC regulations.

See how we can support your ADC development. Request a consult with our ADC experts!

Streamline your ADC development with our additional benefits:

Contact our experts to advance your ADC programs today!

Keep your ADC programs on Target | CellCarta

Keep your ADC programs on Target

Our experts harness our comprehensive suite of precision assays to measure what matters throughout your ADC development. Navigate the complexities of ADC development and approval with our scientific & regulatory expertise.

Discover our ADC expertise. Request a consult today.

On Target:

Our multiplatform approach for reliable ADC analysis ensures you have a complete understanding of your target expression, engagement and ADC pharmacokinetics at all stages of development.

Download the resource

See our precision assays for ADC development

Beyond the target:

In-depth monitoring of the tumor microenvironment (TME) is crucial to understanding why patients may or may not respond to ADCs. We assess immune cell infiltration, activation and exhaustion with multiplatform approaches, plus spatial distribution of cells and targets including both transcriptomic and proteomic profiling.

On-target, off-tumor:

We understand that safety is key. Precisely assessing on-target, off-tumor ADC toxicity identifies concerns early.

On track for approval:

We conduct all assays using CAP/CLIA-accredited laboratories, ensuring the highest standards for regulatory compliance. Our team supports your pathway to approval with extensive knowledge on IVDR and HGRAC regulations.

See how we can support your ADC development. Request a consult with our ADC experts!

Streamline your ADC development with our additional benefits:

Contact our experts to advance your ADC programs today!

Biomarker strategies to support success at every stage of therapy development

April 3, 2025

Precision Medicine Solutions: Biomarker strategies to support success at every stage of therapy development

 

Biomarker strategies to support success at every stage of therapy development

April 3, 2025

Precision Medicine Solutions: Biomarker strategies to support success at every stage of therapy development

 

Supporting Your Targeted Protein Degradation Strategies

April 1, 2025

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TPD

Supporting Your Targeted Protein Degradation Strategies

April 1, 2025

DOWNLOAD OUR INFOGRAPHIC

TPD