#-supreme-cellcarta-cta-banner-17-144{items-data:[{"faq_question":"What ADC biomarkers do you support?","faq_answer":"<p>We offer validated IHC assays for established ADC targets,including HER2,cMET,B7H3,TROP2,DLL3,EGFR,and Nectin2. We're also actively developing assays for emerging targets,including B7-H4,HER3,ROR1,CEACAM5,and STEAP1,with additional biomarkers coming soon.</p>"},{"faq_question":"How,and to what extent,must the ADC target be expressed on cancer cells? ","faq_answer":"Target expression is a prerequisite for ADC efficacy. The required level and pattern of expression can vary significantly depending on the ADC and the mechanism of action. CellCarta supports expression analysis across multiple platforms — including IHC,IF,flow cytometry,and mass spectrometry — to help you determine the threshold and distribution of target expression needed for your program."},{"faq_question":"What assay technologies are available? ","faq_answer":"Our ADC platform spans singleplex and multiplex IHC,multiplex immunofluorescence with up to 40 markers per slide,in-situ hybridization (ISH/RNAscope),and FISH. This multi-modal approach allows us to characterise target expression at the protein,RNA,and genomic level within the same tissue context. "},{"faq_question":"How do you assess ADC killing of target cells? ","faq_answer":"Assessing ADC killing efficiency requires evaluating multiple downstream events:target engagement,internalization,linker cleavage,and cytotoxic payload release. CellCarta uses receptor occupancy (RO) assays and transcriptomic approaches (RNAseq,CITE-seq) to indirectly assess binding efficiency and payload activity across both solid and non-solid tumors."},{"faq_question":"Does ADC have on-target,off-tumor effects? ","faq_answer":"Identifying on-target,off-tumor toxicity early is critical for safe ADC development. Our mIF and mIHC platforms evaluate target expression in normal tissues,while flow cytometry tracks circulating target-expressing cell counts as a surrogate for off-target killing. Bulk RNA sequencing and gene set enrichment analysis (GSEA) further investigate activated toxicity pathways. "}];oxy-supreme-cellcarta-cta-banner-items-data:[{"faq_question":"What ADC biomarkers do you support?","faq_answer":"<p>We offer validated IHC assays for established ADC targets,including HER2,cMET,B7H3,TROP2,DLL3,EGFR,and Nectin2. We're also actively developing assays for emerging targets,including B7-H4,HER3,ROR1,CEACAM5,and STEAP1,with additional biomarkers coming soon.</p>"},{"faq_question":"How,and to what extent,must the ADC target be expressed on cancer cells? ","faq_answer":"Target expression is a prerequisite for ADC efficacy. The required level and pattern of expression can vary significantly depending on the ADC and the mechanism of action. CellCarta supports expression analysis across multiple platforms — including IHC,IF,flow cytometry,and mass spectrometry — to help you determine the threshold and distribution of target expression needed for your program."},{"faq_question":"What assay technologies are available? ","faq_answer":"Our ADC platform spans singleplex and multiplex IHC,multiplex immunofluorescence with up to 40 markers per slide,in-situ hybridization (ISH/RNAscope),and FISH. This multi-modal approach allows us to characterise target expression at the protein,RNA,and genomic level within the same tissue context. "},{"faq_question":"How do you assess ADC killing of target cells? ","faq_answer":"Assessing ADC killing efficiency requires evaluating multiple downstream events:target engagement,internalization,linker cleavage,and cytotoxic payload release. CellCarta uses receptor occupancy (RO) assays and transcriptomic approaches (RNAseq,CITE-seq) to indirectly assess binding efficiency and payload activity across both solid and non-solid tumors."},{"faq_question":"Does ADC have on-target,off-tumor effects? ","faq_answer":"Identifying on-target,off-tumor toxicity early is critical for safe ADC development. Our mIF and mIHC platforms evaluate target expression in normal tissues,while flow cytometry tracks circulating target-expressing cell counts as a surrogate for off-target killing. Bulk RNA sequencing and gene set enrichment analysis (GSEA) further investigate activated toxicity pathways. "}]}#-supreme-cellcarta-faq-13-144{items-data:[{"faq_question":"What ADC biomarkers do you support?","faq_answer":"<p>We offer validated IHC assays for established ADC targets,including HER2,cMET,B7H3,TROP2,DLL3,EGFR,and Nectin2. We're also actively developing assays for emerging targets,including B7-H4,HER3,ROR1,CEACAM5,and STEAP1,with additional biomarkers coming soon.</p>"},{"faq_question":"How,and to what extent,must the ADC target be expressed on cancer cells? ","faq_answer":"<p>Target expression is a prerequisite for ADC efficacy. The required level and pattern of expression can vary significantly depending on the ADC and the mechanism of action. CellCarta supports expression analysis across multiple platforms &mdash;including <a href=\"/capabilities/histopathology/if-ihc/\" target=\"_self\">IHC and IF</a>,<a href=\"/platforms/flow-cytometry/\" target=\"_self\">flow cytometry</a>,and <a href=\"/platforms/mass-spectrometry/\" target=\"_self\">mass spectrometry</a> &mdash;to help you determine the threshold and distribution of target expression needed for your program.</p>"},{"faq_question":"What assay technologies are available? ","faq_answer":"<p>Our ADC spans singleplex and <a href=\"/capabilities/histopathology/if-ihc/\" target=\"_self\">mIHC,mIF</a> with up to 40 markers per slide,<em>in situ</em> hybridization (ISH/RNAscope),and <a href=\"/platforms/mass-spectrometry/\" target=\"_self\">mass spectrometry</a>. This multi-modal approach allows us to characterize target expression at the protein,RNA,and genomic level within the same tissue context,supporting the advancement of your program&rsquo;s ADC platform.</p>"},{"faq_question":"How do you assess ADC killing of target cells? ","faq_answer":"<p>Assessing ADC killing efficiency requires evaluating multiple downstream events:target engagement,internalization,linker cleavage,and cytotoxic payload release. CellCarta uses various assays,including <a href=\"/capabilities/immune-monitoring/receptor-occupancy-assays/\" target=\"_self\">receptor occupancy (RO) assays</a>,and approaches (<a href=\"/capabilities/genomics/sequencing-services/rnaseq/\" target=\"_self\">RNAseq</a>,<a href=\"/capabilities/genomics/sequencing-services/single-cell-sequencing/\" target=\"_self\">CITE-seq</a>) to assess both binding efficiency and payload activity across tissue and liquid samples.</p>"},{"faq_question":"Does ADC have on-target,off-tumor effects? ","faq_answer":"<p>Identifying on-target,off-tumor toxicity early is critical for safe ADC platform development. Our <a href=\"/capabilities/histopathology/if-ihc/\" target=\"_self\">mIF and mIHC platforms</a> evaluate target expression in normal tissues,while <a href=\"/platforms/flow-cytometry/\" target=\"_self\">flow cytometry</a> tracks circulating target-expressing cell counts as a surrogate for off-target killing. <a href=\"/capabilities/genomics/sequencing-services/rnaseq/\" target=\"_self\">Bulk RNA sequencing</a> and gene set enrichment analysis (GSEA) further investigate activated toxicity pathways.</p>"}]}#-supreme-cellcarta-featured-resources-16-144{cards-data:[{"image_url":"\/wp-content\/uploads\/2026\/05\/webinar.jpg","card_type":"Webinar","date":"Feb 12","reading_time":"Reading Time - 5 minutes","title":"Resources Title Goes Here","description":"Lorem ipsum dolor sit amet,consectetuer adipiscing elit. Aenean commodo ligula eget dolor.","url":"#"},{"image_url":"\/wp-content\/uploads\/2026\/05\/webinar-2.jpg","card_type":"Webinar","date":"Feb 12","reading_time":"Reading Time - 5 minutes","title":"Resources Title Goes Here","description":"Lorem ipsum dolor sit amet,consectetuer adipiscing elit. Aenean commodo ligula eget dolor.","url":"#"},{"image_url":"\/wp-content\/uploads\/2026\/05\/webinar-3.jpg","card_type":"Webinar","date":"Feb 12","reading_time":"Reading Time - 5 minutes","title":"Resources Title Goes Here","description":"Lorem ipsum dolor sit amet,consectetuer adipiscing elit. Aenean commodo ligula eget dolor.","url":"#"}]}#-supreme-cellcarta-infobox-24-176{tabs-data:[{"tab_title":"Confirm Target Engagement ","content_title":"","content_body":"<p>Depending on your study,we can incorporate multiple ADC assays to measure target engagement.</p>\n<p>Receptor occupancy assays and transcriptomic analysis confirm target binding,with continuous image scoring and analysis for clinical endpoints. For early-stage programs,we also support reagent-free <a href=\"../../platforms/mass-spectrometry/\" target=\"_self\">mass spectrometry</a>.</p>\n<p><a href=\"../../capabilities/histopathology/if-ihc/\" target=\"_self\">Immunohistochemistry (IHC) assays</a> can assess expression in solid tumor tissue,while <a href=\"../../platforms/flow-cytometry/\" target=\"_self\">flow cytometry</a> is suited for liquid biopsies.</p>","tab_image":"https://cellcarta.com/wp-content/uploads/2026/06/Validate-Target-Engagement-133.jpg","image_alt":""},{"tab_title":"Map the TME","content_title":"","content_body":"<p>We can support mapping of the tumor microenvironment (TME),critical for understanding patient response to ADC platforms.</p>\n<p>To assess immune cell populations and guide patient selection,we can use various platforms,such as<a href=\"../../capabilities/histopathology/if-ihc/\" target=\"_self\"> multiplex IHC</a>,<a href=\"../../capabilities/genomics/sequencing-services/single-cell-sequencing/\" target=\"_self\">CITE-seq</a>,<a href=\"../../capabilities/genomics/sequencing-services/rnaseq/\" target=\"_self\">bulk RNAseq</a>,and <a href=\"../../platforms/flow-cytometry/\" target=\"_self\">flow cytometry</a>.</p>\n<p>Our <a href=\"../../capabilities/histopathology/spatial-biology/\" target=\"_self\">advanced spatial platforms</a> &mdash;Visium,GeoMx,COMET &mdash;can layer in added proteomic and genomic analysis to explore cellular phenotype,distribution,and function.</p>","tab_image":"https://cellcarta.com/wp-content/uploads/2026/07/Lunaphore-COMET.png","image_alt":""},{"tab_title":"Track Stability and Toxicity","content_title":"","content_body":"<p>Track ADC stability and concentration through our <a href=\"../../platforms/mass-spectrometry/\" target=\"_self\">advanced mass spectrometry-based workflow</a>,capable of supporting all stages of therapeutic development.</p>\n<p>For toxicity,we can assess target expression in normal tissues via <a href=\"../../capabilities/histopathology/if-ihc/\" target=\"_self\">mIF and mIHC</a>,track circulating target expressing cells by <a href=\"../../platforms/flow-cytometry/\" target=\"_self\">flow cytometry</a>,and investigate toxicity pathways through <a href=\"../../capabilities/genomics/sequencing-services/rnaseq/\" target=\"_self\">bulk RNA sequencing</a> and gene set enrichment analysis.</p>","tab_image":"https://cellcarta.com/wp-content/uploads/2026/06/Manage-Toxicity-96.jpg","image_alt":""},{"tab_title":"Biobank and Global Presence","content_title":"","content_body":"<p>Accelerate assay development and validation with access to our regulated Biobank,containing over 5,000 consent confirmed and quality checked FFPE and blood samples. This enables immediate study initiation without delay.</p>\n<p>When your ADC platform program is ready to scale,our fully owned and accredited laboratory network across the US,Canada,Belgium,China,and Australia gives you standardized workflows and end-to-end CDx services globally.</p>","tab_image":"https://cellcarta.com/wp-content/uploads/2026/06/Biobank-176.jpg","image_alt":""}];oxy-supreme-cellcarta-infobox-tabs-data:[{"tab_title":"Confirm Target Engagement ","content_title":"","content_body":"<p>Depending on your study,we can incorporate multiple ADC assays to measure target engagement.</p>\n<p>Receptor occupancy assays and transcriptomic analysis confirm target binding,with continuous image scoring and analysis for clinical endpoints. For early-stage programs,we also support reagent-free <a href=\"../../platforms/mass-spectrometry/\" target=\"_self\">mass spectrometry</a>.</p>\n<p><a href=\"../../capabilities/histopathology/if-ihc/\" target=\"_self\">Immunohistochemistry (IHC) assays</a> can assess expression in solid tumor tissue,while <a href=\"../../platforms/flow-cytometry/\" target=\"_self\">flow cytometry</a> is suited for liquid biopsies.</p>","tab_image":"https://cellcarta.com/wp-content/uploads/2026/06/Validate-Target-Engagement-133.jpg","image_alt":""},{"tab_title":"Map the TME","content_title":"","content_body":"<p>We can support mapping of the tumor microenvironment (TME),critical for understanding patient response to ADC platforms.</p>\n<p>To assess immune cell populations and guide patient selection,we can use various platforms,such as<a href=\"../../capabilities/histopathology/if-ihc/\" target=\"_self\"> multiplex IHC</a>,<a href=\"../../capabilities/genomics/sequencing-services/single-cell-sequencing/\" target=\"_self\">CITE-seq</a>,<a href=\"../../capabilities/genomics/sequencing-services/rnaseq/\" target=\"_self\">bulk RNAseq</a>,and <a href=\"../../platforms/flow-cytometry/\" target=\"_self\">flow cytometry</a>.</p>\n<p>Our <a href=\"../../capabilities/histopathology/spatial-biology/\" target=\"_self\">advanced spatial platforms</a> &mdash;Visium,GeoMx,COMET &mdash;can layer in added proteomic and genomic analysis to explore cellular phenotype,distribution,and function.</p>","tab_image":"https://cellcarta.com/wp-content/uploads/2026/07/Lunaphore-COMET.png","image_alt":""},{"tab_title":"Track Stability and Toxicity","content_title":"","content_body":"<p>Track ADC stability and concentration through our <a href=\"../../platforms/mass-spectrometry/\" target=\"_self\">advanced mass spectrometry-based workflow</a>,capable of supporting all stages of therapeutic development.</p>\n<p>For toxicity,we can assess target expression in normal tissues via <a href=\"../../capabilities/histopathology/if-ihc/\" target=\"_self\">mIF and mIHC</a>,track circulating target expressing cells by <a href=\"../../platforms/flow-cytometry/\" target=\"_self\">flow cytometry</a>,and investigate toxicity pathways through <a href=\"../../capabilities/genomics/sequencing-services/rnaseq/\" target=\"_self\">bulk RNA sequencing</a> and gene set enrichment analysis.</p>","tab_image":"https://cellcarta.com/wp-content/uploads/2026/06/Manage-Toxicity-96.jpg","image_alt":""},{"tab_title":"Biobank and Global Presence","content_title":"","content_body":"<p>Accelerate assay development and validation with access to our regulated Biobank,containing over 5,000 consent confirmed and quality checked FFPE and blood samples. This enables immediate study initiation without delay.</p>\n<p>When your ADC platform program is ready to scale,our fully owned and accredited laboratory network across the US,Canada,Belgium,China,and Australia gives you standardized workflows and end-to-end CDx services globally.</p>","tab_image":"https://cellcarta.com/wp-content/uploads/2026/06/Biobank-176.jpg","image_alt":""}]}#-supreme-cellcarta-service-blocks-45-176{blocks-data:[{"image":"https://cellcarta.com/wp-content/uploads/2026/06/Sample-Logistics-tab-408.jpg","image_alt":"","title":"Sample Logistics","description":"Global sample management,transport,and biorepository services with real-time tracking. ","button_text":"Explore Sample Logistics","button_url":"/clinical-trial-services/sample-logistics/","button_target":"_self"},{"image":"https://cellcarta.com/wp-content/uploads/2026/07/21-Biomarker-Solutions-Hero.jpg","image_alt":"","title":"Biomarker Solutions ","description":"Multi-platform biomarker strategies from discovery through clinical development. ","button_text":"Explore Biomarker Solutions","button_url":"/capabilities/biomarkers/","button_target":"_self"},{"image":"https://cellcarta.com/wp-content/uploads/2026/06/CDx-Development-hero-64.jpg","image_alt":"","title":"CDx Development ","description":"Advance clinical trial assays into approved,commercially viable CDx programs with unmatched flexibility. ","button_text":"Explore CDx solutions","button_url":"/clinical-trial-services/cdx-development/","button_target":"_self"}]}#-supreme-cellcarta-tab-content-11-144{tabs-data:[{"tab_title":"Confirm Target Engagement ","content_title":"","content_body":"<p>Depending on your study,we can incorporate multiple ADC assays to measure target engagement.</p>\n<p>Receptor occupancy assays and transcriptomic analysis confirm target binding,with continuous image scoring and analysis for clinical endpoints. For early-stage programs,we also support reagent-free <a href=\"/platforms/mass-spectrometry/\" target=\"_self\">mass spectrometry</a>.</p>\n<p><a href=\"/capabilities/histopathology/if-ihc/\" target=\"_self\">Immunohistochemistry (IHC) assays</a> can assess expression in solid tumor tissue,while <a href=\"/platforms/flow-cytometry/\" target=\"_self\">flow cytometry</a> is suited for liquid biopsies.</p>","tab_image":"https://cellcarta.com/wp-content/uploads/2026/06/Validate-Target-Engagement-133.jpg","image_alt":""},{"tab_title":"Map the TME","content_title":"","content_body":"<p>We can support mapping of the tumor microenvironment (TME),critical for understanding patient response to ADC platforms.</p>\n<p>To assess immune cell populations and guide patient selection,we can use various platforms,such as<a href=\"/capabilities/histopathology/if-ihc/\" target=\"_self\"> multiplex IHC</a>,<a href=\"/capabilities/genomics/sequencing-services/single-cell-sequencing/\" target=\"_self\">CITE-seq</a>,<a href=\"/capabilities/genomics/sequencing-services/rnaseq/\" target=\"_self\">bulk RNAseq</a>,and <a href=\"/platforms/flow-cytometry/\" target=\"_self\">flow cytometry</a>.</p>\n<p>Our <a href=\"/capabilities/histopathology/spatial-biology/\" target=\"_self\">advanced spatial platforms</a> &mdash;Visium,GeoMx,COMET &mdash;can layer in added proteomic and genomic analysis to explore cellular phenotype,distribution,and function.</p>","tab_image":"https://cellcarta.com/wp-content/uploads/2026/07/Lunaphore-COMET.png","image_alt":""},{"tab_title":"Track Stability and Toxicity","content_title":"","content_body":"<p>Track ADC stability and concentration through our <a href=\"/platforms/mass-spectrometry/\" target=\"_self\">advanced mass spectrometry-based workflow</a>,capable of supporting all stages of therapeutic development.</p>\n<p>For toxicity,we can assess target expression in normal tissues via <a href=\"/capabilities/histopathology/if-ihc/\" target=\"_self\">mIF and mIHC</a>,track circulating target expressing cells by <a href=\"/platforms/flow-cytometry/\" target=\"_self\">flow cytometry</a>,and investigate toxicity pathways through <a href=\"/capabilities/genomics/sequencing-services/rnaseq/\" target=\"_self\">bulk RNA sequencing</a> and gene set enrichment analysis.</p>","tab_image":"https://cellcarta.com/wp-content/uploads/2026/06/Manage-Toxicity-96.jpg","image_alt":""},{"tab_title":"Biobank and Global Presence","content_title":"","content_body":"<p>Accelerate assay development and validation with access to our regulated Biobank,containing over 5,000 consent confirmed and quality checked FFPE and blood samples. This enables immediate study initiation without delay.</p>\n<p>When your ADC platform program is ready to scale,our fully owned and accredited laboratory network across the US,Canada,Belgium,China,and Australia gives you standardized workflows and end-to-end CDx services globally.</p>","tab_image":"https://cellcarta.com/wp-content/uploads/2026/06/Biobank-176.jpg","image_alt":""}]}