Cytométrie en flux
November 9, 2020
Monitoring MDSC – A Hurdle to Immune Checkpoints Inhibitors
CellCarta’s poster discusses the challenges of monitoring myeloid-derived suppressor cells (MDSCs), which can hinder the effectiveness of immune checkpoint inhibitors.
The study introduces a standardized method for identifying MDSCs using HLA-DR expression levels to distinguish between low and high MDSC populations. This approach was validated in a clinical study with melanoma patients undergoing pembrolizumab treatment, showing a correlation between high MDSC levels and reduced survival rates.
The MDSC phenotyping assay developed by CellCarta offers a reliable tool for assessing MDSC impact on immunotherapy and improving treatment strategies.
As presented in SITC 2020
