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Single-Cell Sequencing Services

Harness the power of our single-cell sequencing platforms for in-depth cellular insights into proteomics, genomics, and beyond.

Talk with Our Experts
Scientist performing single cell sequencing at a laboratory bench.

Powerful Cellular Insight

Our single-cell sequencing platforms provide high-resolution data that is often missed when using lower plex single cell platforms, providing crucial insights for rare cell subsets, dynamic cell states, and predictive biomarkers. 

CellCarta is a Certified Service Provider on the 10X Genomics Chromium X platform, which provides multiple types of omics readouts tailored to your study needs. 

Our single-cell sequencing services can scale to meet your study at any stage of the drug development process.  

Our Single-Cell Sequencing Capabilities

As a 10X Genomics Certified Service Provider, several different omics readouts are possible. CellCarta offers the following services, suited to studies at any stage:

  • scRNA-seq (single cell RNA sequencing) of RNA
  • CITE-seq (Cellular Indexing of Transcriptomes and Epitopes sequencing) of RNA and proteins
  • Repertoire profiling of RNA, T-cell receptors (TCR), and B-cell receptors (BCR)
  • Immune profiling of RNA, proteins, TCR and/or BCR

Our workflows adapt to your study’s needs, and include:

  • 5’ Single Cell Immune Profiling: Whole transcriptome data with the option to add protein marker detection, TCR/BCR sequencing, and antigen mapping.
  • 3’ Single Cell Gene Expression: Whole transcriptome data with the option to add protein expression data.
  • Flex Fixed RNA Profiling: Most sensitive and cost-effective option for whole transcriptome data with the option to add protein expression data.

Our single-cell RNA sequencing assays can be supported with various upstream immunology services to ensure your experimental needs are met with the highest standard of quality. These services include:

  • Cell culture
  • Compound treatment
  • FACS-based cell sorting
  • Magnetic enrichment
  • Dead cell removal

Single-cell sequencing analysis is done on our CellEngine software, mirroring traditional flow cytometry analysis. Our software uses familiar interactive visualization tools and supports tSNE and UMAP clustering.

We offer a range of study deliverables, including:

  • Raw FASTQ files
  • Summary QC report
  • 10X cell ranger outputs (web summary, Loupe, H5 files)
  • Slide decks
  • Written reports

When needed, custom bioinformatics services are also available.

Our single-cell sequencing platforms can analyze a variety of clinical sample types, including both solid tissue and liquid biopsy samples. These include:

  • Cryopreserved and fresh PBMCs
  • Lysed whole blood
  • Cell lines
  • Fixed samples

Our single-cell sequencing services will adapt and optimize to your study’s specifications, no matter your matrix of choice.

As a 10X Genomics Certified Service Provider, several different omics readouts are possible. CellCarta offers the following services, suited to studies at any stage:

  • scRNA-seq (single cell RNA sequencing) of RNA
  • CITE-seq (Cellular Indexing of Transcriptomes and Epitopes sequencing) of RNA and proteins
  • Repertoire profiling of RNA, T-cell receptors (TCR), and B-cell receptors (BCR)
  • Immune profiling of RNA, proteins, TCR and/or BCR
Loading a sample into the 10X Genomics Chromium instrument.

Our workflows adapt to your study’s needs, and include:

  • 5’ Single Cell Immune Profiling: Whole transcriptome data with the option to add protein marker detection, TCR/BCR sequencing, and antigen mapping.
  • 3’ Single Cell Gene Expression: Whole transcriptome data with the option to add protein expression data.
  • Flex Fixed RNA Profiling: Most sensitive and cost-effective option for whole transcriptome data with the option to add protein expression data.
Sequencing Services

Our single-cell RNA sequencing assays can be supported with various upstream immunology services to ensure your experimental needs are met with the highest standard of quality. These services include:

  • Cell culture
  • Compound treatment
  • FACS-based cell sorting
  • Magnetic enrichment
  • Dead cell removal
Scientist using a centrifuge for sample processing.

Single-cell sequencing analysis is done on our CellEngine software, mirroring traditional flow cytometry analysis. Our software uses familiar interactive visualization tools and supports tSNE and UMAP clustering.

We offer a range of study deliverables, including:

  • Raw FASTQ files
  • Summary QC report
  • 10X cell ranger outputs (web summary, Loupe, H5 files)
  • Slide decks
  • Written reports

When needed, custom bioinformatics services are also available.

Advanced Analysis Tab 296

Our single-cell sequencing platforms can analyze a variety of clinical sample types, including both solid tissue and liquid biopsy samples. These include:

  • Cryopreserved and fresh PBMCs
  • Lysed whole blood
  • Cell lines
  • Fixed samples

Our single-cell sequencing services will adapt and optimize to your study’s specifications, no matter your matrix of choice.

Scientist pipetting beside reagent storage shelves.
Scientist loading samples for single cell sequencing.

Clinical Applications

Single-cell sequencing has several possible applications, including immunotherapy, cell therapy, protein degradation, and vaccines.

Our team can tailor our single-cell sequencing services to best support your intended application.

Why CellCarta

From start to finish, our single-cell sequencing services are built for the complexity your program demands.

10X Genomics Provider

Flexible Sample Inputs

Adaptable Workflows

Robust Analytical Workflow

Full Study Coverage

Looking to incorporate single-cell sequencing?

Our single-cell sequencing platforms can provide high-resolution cellular information suitable for a range of clinical studies.

Scientist performing single cell sequencing at a laboratory bench.

Frequently Asked Questions

Single-cell sequencing analysis is applicable at any stage of drug development, from early discovery and preclinical animal studies through to clinical trials and reverse translation.

By profiling individual cells, researchers can identify rare cell populations, characterize immune responses, and uncover mechanisms of drug action that bulk methods would obscure. Whether you are evaluating a candidate therapy or analyzing clinical samples post-treatment, our single-cell sequencing services are designed to scale with your program.

As a 10X Genomics Certified Service Provider, CellCarta offers scRNA-seq, CITE-seq, repertoire profiling, and immune profiling on the Chromium X single cell sequencing platform.

These assays enable simultaneous readout of whole transcriptome data, protein expression, and TCR or BCR repertoire information. Workflows include 5' Single Cell Immune Profiling, 3' Single Cell Gene Expression, and Flex Fixed RNA Profiling, giving you the flexibility to match assay depth to your specific study objectives.

Our single cell sequencing platforms are compatible with a range of clinical sample types, including cryopreserved PBMCs, lysed whole blood, fresh PBMCs, cell lines, and fixed samples. Both solid and liquid biopsy inputs are supported.

For samples requiring upstream preparation, CellCarta offers integrated immunology services including FACS-based cell sorting, magnetic enrichment, dead cell removal, cell culture, and compound treatment, all performed in-house prior to sequencing.

Single cell sequencing analysis is performed using CellEngine, CellCarta's proprietary software, which mirrors familiar flow cytometry analysis workflows.

Deliverables include raw FASTQ files, summary QC reports, 10X Cell Ranger outputs (web summary, Loupe, and H5 files), slide decks, and written reports. Interactive visualization tools including tSNE and UMAP clustering are available through CellEngine. Custom bioinformatics services are also offered for studies requiring specialized analysis.

Single cell sequencing services support a broad range of clinical applications, including immunotherapy, cell therapy, protein degradation studies, and vaccine development. The technology enables high-resolution characterization of immune cell populations, T cell and B cell receptor diversity, and gene expression at the single-cell level.

Our team works with you to tailor our single-cell sequencing services to your specific therapeutic area and study stage.