Go beyond quantification and unlock the full potential of your therapeutic program by analyzing gene and protein expression within the tissue context.
CellCarta has extensive expertise implementing spatial biology techniques validated for use in any preclinical and clinical study. We offer standard and custom panels development for spatial biology platforms that can provide a comprehensive genomic, proteomic, and cellular insights for your tissue samples.
The 10x Genomics Visium spatial gene expression platform maps the whole transcriptome for your entire sample at single-cell resolution. We use the Visium CytAssist instrument to streamline this workflow, ensuring precise alignment while maximizing sample use.
Using the Visium HD workflow, researchers get unbiased, whole sample gene expression analysis with spatial context from CellCarta’s experienced spatial team.
The NanoString GeoMX® Digital Spatial Profiler (DSP) provides targeted, high-plex RNA and protein expression analysis in hypothesis-driven regions of interest (ROIs). Morphology markers highlight tissue architecture and marker localization so your team can select only biologically relevant ROIs.
The GeoMx DSP panel portfolio includes whole transcriptome profiling (WTA) and the 570 protein IPA panel, which can be run together for multi-omic capabilities.
The Lunaphore COMET™ platform performs automated multiplex immunofluorescence (mIF) with high reproducibility at single-cell resolution, supporting both protein and RNA targets.
COMET uses unconjugated primary antibodies, making panel development easy and cost effective. An extensive array of off-the-shelf panels is available, eliminating the need for a long assay development process.
Our histology expertise enhances COMET’s adaptability while our Bio-IT capabilities translate proteomic data into discovery.
The 10x Genomics Visium spatial gene expression platform maps the whole transcriptome for your entire sample at single-cell resolution. We use the Visium CytAssist instrument to streamline this workflow, ensuring precise alignment while maximizing sample use.
Using the Visium HD workflow, researchers get unbiased, whole sample gene expression analysis with spatial context from CellCarta’s experienced spatial team.
The NanoString GeoMX® Digital Spatial Profiler (DSP) provides targeted, high-plex RNA and protein expression analysis in hypothesis-driven regions of interest (ROIs). Morphology markers highlight tissue architecture and marker localization so your team can select only biologically relevant ROIs.
The GeoMx DSP panel portfolio includes whole transcriptome profiling (WTA) and the 570 protein IPA panel, which can be run together for multi-omic capabilities.
The Lunaphore COMET™ platform performs automated multiplex immunofluorescence (mIF) with high reproducibility at single-cell resolution, supporting both protein and RNA targets.
COMET uses unconjugated primary antibodies, making panel development easy and cost effective. An extensive array of off-the-shelf panels is available, eliminating the need for a long assay development process.
Our histology expertise enhances COMET’s adaptability while our Bio-IT capabilities translate proteomic data into discovery.
Each platform offers unique advantages. Generate your hypotheses with broad transcriptomic profiling using GeoMx® DSP, or through high-resolution tissue mapping with Visium HD. COMET’s unparallel precision can then test your hypotheses, making it an essential part of the therapeutic development pipeline.
Unlock the full value of multiplex immunofluorescence data with SPARTA (Spatial Phenotyping and Analysis in Regions of Tissue with AI), CellCarta's framework for mIF analysis. SPARTA standardizes how datasets are processed and analyzed across imaging systems to easily extract meaningful insights.
When challenges arise during clinical trials, a rapid, coordinated response is required to prevent unexpected delays. Thanks to our Lake Forest team’s expertise and quick thinking, they rescued a pilot study using the COMET platform when issues initially arose regarding sample sourcing.
Consider combining our spatial biology platforms with other key services to expand your clinical data further.
Cutting-edge digital and AI-powered pathology services to advance your clinical trials.
Insights into the abundance, distribution, and localization of your antigen of interest.
Integrated proteomics platforms for discovery, quantification, and clinical testing.
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Spatial biology is the study of cells within their native environment. By preserving tissue architecture, it allows researchers to investigate cellular distribution, interactions, and changes in response to environmental stimuli, providing a more complete picture of disease biology than conventional assays or single-cell approaches alone.
Spatial biology provides deeper insight into the cellular context of disease. Clinical benefits include enhanced drug targeting, a better understanding of a candidate therapeutic’s mechanism of action, improved patient stratification and monitoring, and accelerated biomarker discovery that correlates spatial patterns with clinical outcomes.
Each platform has distinct strengths. Visium HD provides high-resolution transcriptomic mapping with morphological context, while GeoMx® Digital Spatial Profiler enables simultaneous whole transcriptome and protein profiling across more than 570 targets from FFPE samples. Together, these tools support hypothesis generation. The COMET platform then enables hypothesis validation with up to 40-plex staining at single-cell resolution, making it a powerful precision tool for spatial analysis.
CellCarta supports your spatial biology program end-to-end, including sample pre-processing, instrument operation, image analysis, and final reporting. Our spatial biology workflows have been validated for preclinical and clinical applications, ensuring your data meets the standards required for therapeutic development programs.
