Alternative Name(s): PHAS-1
Test Description
The eukaryotic initiation factor 4E binding protein 1 (4E-BP1) binds to eukaryotic initiation factor 4E (eIF-4E) to prevent translation initiation. The pathway leading to 4E-BP1 phosphorylation involves phosphoinositide 3-kinase (PI3K) and its downstream effector, the serine–threonine kinase AKT.