Alternative Name(s): Excision Repair Cross-Complementation Group 1, RAD10
Test Description
ERCC1 is important for resistance to platinum agents. The function of the ERCC1 protein is predominantly in nucleotide excision repair (NER) of damaged DNA. Measuring ERCC1 activity may have clinical utility, because a mechanism of resistance to platinum chemotherapy drugs correlates with high ERCC1 activity.