Alternative Name(s): H2A Histone Family Member X
Test Description
DNA damage involves double-strand breaks (DSB) and triggers phosphorylation of histone H2AX, a variant of the nucleosome core histone H2A family. Stress signals such as replication stress, endogenous stress, ionizing radiation, and DNA damaging agents can initiate DNA damage and subsequent expression of pH2AX. Phosphorylation of H2AX at Serine 139 (Ser139) correlates well with DSB and is a sensitive marker to examine DNA damage.