Alternative Name(s): RB1, Retinoblastoma
Test Description
The retinoblastoma (Rb) tumor suppressor protein is a nuclear phosphoprotein that regulates cell proliferation by controlling progression through the restriction point within the G1-phase of the cell cycle. Phosphorylation of Rb changes with the cell cycle and exists in the hypo-phosphorylated state in early G1-phase and is regulated by cyclin-dependent kinase (CDK) inhibitors.