TIGIT

T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a co-inhibitory receptor expressed on activated T cells, memory T cells, follicular T helper cells, T regulatory cells, natural killer (NK) cells, and tumor cells. TIGIT binds with high affinity to the human poliovirus receptor (PVR) and suppresses T cell responses by directly interacting with the T cell receptor (TCR) affecting the signaling cascade and promoting the generation of mature immunoregulatory dendritic cells.