Powering histopathology with cutting-edge digital image analysis

From slide to digital data

As a first adopter of digital whole slide high-resolution image capture and with nearly two decades of operations, we have resolved and pioneered multiple imaging and image analysis methodologies that are ideal for clinical trial deployment. All our services are guided by carefully optimized and rigorously documented procedures.

Key services include:

  • Pathologist-directed image analysis
  • Digital whole-slide brightfield and fluorescent scanning
  • Multispectral imaging
  • Dedicated team of imaging scientists, image analysts, and application experts, implementing customized and commercial algorithms

Each slide is digitally captured in high-resolution, whole-slide format and retained on our image servers. The larger part of the evaluation and scoring is performed by our team of trained pathologists and imaging scientists. Image scanning and analysis for clinical trials is performed in a CLIA-certified, CAP accredited laboratory.

Whole slide scanning

At CellCarta, we use industry-standard scanning technology, like fluorescent and brightfield scanners from 3DHistech, Akoya, BioView, Leica Biosystems (Aperio®), Roche/Ventana, and Zeiss to enable high throughput, high resolution imaging with a fast turnaround time.

Whole slide scanning is a strategic solution for digital image archiving, image analysis, and sharing of staining results. We can provide whole-slide scanning as part of our end-to-end digital pathology services, or as a stand-alone service for your digitization programs.

Digital image analysis

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Our broad portfolio of image analysis tools includes Indica Labs’ HALO®, Visiopharm®Akoya’s inForm®, CyteHub®, SoloWeb, and navify® by Roche. Our team can capture valuable data from tissues including cell phenotypes, densities and spatial biology running commercially validated assays in addition to developing custom algorithms allows us to extract the information that matters for your clinical programs.

Image Analysis Capabilities

  • H&E, IHC, IF, single and multiplexed, brightfield and fluorescent image analysis
  • Spatial biology measurements and nearest neighbor analysis
  • Stereology based methods for systematic uniform random sampling of ROIs for pathologist scoring e.g. for microvessel density
  • Image analysis algorithms developed by our scientists and validated according to CellCarta’s quality standards

Our team of scientists is always available for consultation to help make sense of the expansive datasets generated for your trials.

AI-powered pathology

Our digital pathology workflows are powered by AI. Whether it’s to detect CTCs, for nuclear segmentation, tissue classification or cell phenotyping, AI is embedded in all our image analysis platforms.

We offer our expertise in developing and validating new AI-based algorithms for your studies, or we can collaborate with your preferred digital pathology AI provider to apply their algorithms in your clinical trial assays conducted at CellCarta.