Technology
Spatial biology encompasses a series of techniques that allow detailed analysis of cells within their spatial context.
Researchers can use spatial biology to resolve tissue heterogeneity and better understand cell-cell interactions, leading to a better understanding of disease mechanisms and better performing predictive and efficacy monitoring biomarkers.
Using the right spatial biology tools, we can help you :
CellCarta has extensive experience in spatial biology. Armed with the right techniques and expertise, we help you fully unlock its potential for your therapy program and enhance the chance of clinical development success.
Choosing the right technology to match your scientific question is crucial for success in spatial biology. Our experts can help guide you to the optimal approach, ensuring you get the most comprehensive insights from your multi-dimensional data. Get in touch with our experts to discuss your project needs and maximize the value of your spatial analysis.
The 10X Genomics Visium Spatial Gene Expression solution, including Visium HD, maps the whole transcriptome with enhanced resolution in its morphological context. At CellCarta, we utilize the Visium CytAssist to transfer transcriptomic probes from archived H&E sections onto Visium and Visium HD slides, maximizing the use of samples.
Using our validated Visium workflow, we can help you unveil biological architecture in normal and diseased tissues, find novel drug targets, and discover new biomarkers to help optimize your precision therapy development.
Our extensive experience across various tissue types ensures comprehensive data analysis tailored to your project’s needs.
With the NanoString GeoMX Digital Spatial Profiler (DSP) system, we can simultaneously profile the whole transcriptome and >570 protein targets using FFPE samples.
GeoMx’s unique region of interest (ROI) selection and segmentation features empower researchers to select the most relevant tissue compartments and cell types to answer specific biological questions at high throughput.
GeoMx DSP also offers targeted panels, allowing for focused transcriptomic and proteomic profiling. These panels enable cost-efficient, high-throughput analyses tailored to specific biological pathways or disease markers. Using nCounter as the readout, researchers benefit from a precise, highly sensitive, and direct digital quantification of both RNA and protein targets, providing robust data to answer critical research questions.
The COMET platform offers fully automated, sequential immunofluorescence (IF) for multiplex spatial proteomics. It leverages advanced microfluidics to deliver exceptional reproducibility and up to 40-plex staining at single-cell resolution. As an open system, COMET is compatible with many unconjugated primary antibodies and offers flexibility through off-the-shelf panels and custom solutions without requiring specialized reagents or extensive development timelines.
CellCarta’s antibody know-how enhances COMET’s adaptability, enabling applications in biomarker discovery, tumor microenvironment analysis, and precision medicine.
COMET also supports up to 12-plex RNAscope™ on the same slide, making it a true multi-omic solution. This comprehensive capability is especially valuable for cell and gene therapy studies, oncology, and other research areas that benefit from simultaneous proteomic and transcriptomic insights.
Each spatial biology technology offers unique strengths, from broad transcriptomic and proteomic profiling with GeoMx DSP to high-resolution mapping with Visium HD. Together, these tools enable comprehensive hypothesis generation by revealing intricate tissue architectures and biomarker landscapes. The COMET platform stands out as the powerful solution to validate and test those hypotheses with unparalleled precision, making it an essential part of your therapeutic development pipeline.