Alternative Name(s): KRAB-associated Protein-1, TRIM28, TIF1B, RNF96
Test Description
KRAB-associated protein-1 (KAP-1) is a component of heterochromatin and is involved in many functions, such as transcription regulation, differentiation, proliferation, DNA damage repair, apoptosis, and suppression of viral genes. High levels of KAP-1 in its unphosphorylated state are associated with aggressive clinical features in a variety of cancers.