Prostaglandin-endoperoxide synthase enzymes, also known as COX enzymes, come in two distinct forms, COX1 and COX2. Cytochrome c oxidase II (COX2) is induced in response to inflammatory stimuli, such as mitogens, tumor promoters and cytokines. COX2 is transiently induced by inflammatory stimuli and is upregulated at the site of tissue injury, neurodegenerative diseases, and many types of cancer.