Alternative Name(s): Murine Double Minute-2, E3 Ubiquitin-Protein Ligase MDM2, P53-Binding Protein MDM2, ACTFS, HDMX
Test Description
Murine double minute-2 (MDM2) is responsible for the ubiquitination of p53, nearly the most prevalently found gene mutated in associated with human cancers. This proto-oncogene therefore possesses the ability to disrupt normal cell cycling from taking place (specifically inhibiting the progression of the G1 to S phases) and may provoke tumorigenesis through proteasomal degradation by inhibiting p53, or other similar tumor suppressor genes.