Alternative Name(s): Proline-Rich AKT1 Substrate 1, AKT1S1
Test Description
The Akt protein family, also called protein kinase B (PKB), plays an important role in cellular survival pathways by inhibiting apoptotic processes and is one of the major downstream targets of the phosphatidylinositol 3-kinase (PI3K) pathway. PRAS40 (proline-rich Akt substrate 40 kDa) is activated by Akt and phosphorylation of this protein allows it to bind to 14-3-3, a cytosolic anchor protein. PRAS40 also binds mTOR (mammalian target of rapamycin), a highly conserved PI3K protein that is also involved with cellular survival with 2 complexes: mTORC1 (rapamycin-sensitive) and mTORC2 (rapamycin-resistant).