Alternative Name(s): Neuregulin, NRG1, HRG, SMDF
Test Description
Heregulin (HRG), a 44 kDa Type I NRG1 isoform, specifically phosphorylates the Erb-B2 (or HER2/neu) receptor tyrosine kinase (though indirectly, via interaction with Erb-B3 and Erb-B4) and is subsequently involved in cell proliferation, invasion, survival, and differentiation of normal and malignant tissues.