Mucins are high molecular weight glycoproteins expressed by epithelial tissues. They have a high content of clustered oligosaccharides, thereby forming a mucosal protection system against particles and infectious agents at mucosal surfaces. MUC2 is a secreted gel-forming mucin that coats the epithelia of intestines, airways, and other mucus membrane-containing organs. Mucin glycoprotein expression can be altered during the carcinogenic process. In CRC, MUC2 loss is associated with the presence of lymph node metastasis and with worsened survival outcomes.